Retargeting of Viruses to Generate Oncolytic Agents
نویسندگان
چکیده
منابع مشابه
Retargeting of Viruses to Generate Oncolytic Agents
Oncolytic virus therapy is based on the ability of viruses to effectively infect and kill tumor cells without destroying the normal tissues. While some viruses seem to have a natural preference for tumor cells, most viruses require the modification of their tropism to specifically enter and replicate in such cells. This review aims to describe the transductional targeting strategies currently e...
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Most of the oncolytic herpes simplex viruses (HSVs) exhibit a high safety profile achieved through attenuation. They carry defects in virulence proteins that antagonize host cell response to the virus, including innate response, apoptosis, authophagy, and depend on tumor cell proliferation. They grow robustly in cancer cells, provided that these are deficient in host cell responses, which is of...
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In World War I, sulfur mustard or mustard gas was used as a chemical weapon for the first time. Years later, during the imposed war (eight years of holy defense) against the Islamic Republic of Iran, Iraq used this poisonous gas against the soldiers and people of Iranian cities. Many years after the war, many chemical veterans still suffer from its effects. Mustard gas is a strong alkylating su...
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1Genelux Corporation, San Diego Science Center, San Diego, CA 92019, USA 2Department of Radiation Oncology, Rebecca and John Moores Comprehensive Cancer Center, University of California, San Diego, CA 92093, USA 3Department of Biochemistry, University of Wuerzburg, 97074 Wuerzburg, Germany 4Rudolf Virchow Center for Experimental Biomedicine, University of Wuerzburg, 97078 Wuerzburg, Germany 5 I...
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Viruses are commonly thought of as opportunistic organisms that hijack cellular machinery with the ultimate goal of replicating and causing destruction in the host. However, viruses are increasingly being explored as therapeutic agents for a variety of disorders and diseases, including cancers, due to their natural ability to spread to various cell types. Oncolytic viruses are replication-compe...
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ژورنال
عنوان ژورنال: Advances in Virology
سال: 2012
ISSN: 1687-8639,1687-8647
DOI: 10.1155/2012/798526